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Andrea Segrè will introduce the meeting discussing the meaning of the word “diet”, starting from his Greek origin, which is “life style”. Thus, Mediterranean diet should involve relations, conviviality, education, traditions, seasonality, exercise, and not only food.The first speaker, Elliot Berry, will try to answer three questions on the big problem of obesity, that is why is it so difficult to eat less and move more? Why is weight loss so difficult to maintain? Why is activity the solution?Iris Shai will focus on the actual effects of Mediterranean Diet on mobilization of fat storage pools and cardio-metabolic health, presenting evidences from long- term clinical trials.Kieran Tuohy will underline how microbe interaction in the gut can reduce chronic disease risk.